Automatic Segmentation to Cluster Patterns of Breathing in Sleep Apnea.

Abstract

Annotation of polysomnography (PSG) recordings for diagnosis of obstructive sleep apnea (OSA) is a standard procedure but an expensive and time-consuming process for clinicians. To aid clinicians in this process we present a data driven unsupervised hierarchical clustering approach for detection and visual presentation of breathing patterns in PSG recordings. The aim was to develop a model independent of manual annotations to detect and visualize respiratory events related to OSA. 10 recordings from the Sleep Heart Health Study database were used, and the proposed algorithm was evaluated based on the manually annotated events for each recording. The algorithm reached an F1-score of 0.58 across the 10 recordings when detecting the presence of an event vs. no event and a 100% correct diagnosis prediction of OSA when predicting if apnea-hypopnea index (AHI) ≥ 15, which is a clinically meaningful cut-off. The F1-score may be due to imprecise placement of events, difficulty distinguishing between hypopneas and stable breathing, and variations in scoring. In conclusion the performance can be improved despite the strong agreement in diagnostics. The method is a proof of concept that a clustering method can detect and visualize breathing patterns related to OSA while maintaining a correct diagnosis.