Automatic segmentation of nuclei from pap smear cell images: A step toward cervical cancer screening

Abstract

AbstractCervical cancer is identified as the fourth most recurrent cancer among women across the globe. The cancer is treatable, if identified at the early stage. Pap smear test is the most common and the best tool for initial screening of cancer. Pap smear cell level image analysis is an open issue. The limitation of the analysis is due to the complexity of the cell structure. The smear cell image is composed of cytoplasm and nucleus. The shape and structure of the nucleus determines the cancer prevalence. Segmentation of nucleus is an important step in cancer detection. There are various methods developed for nucleus segmentation. The article proposes multithresholding algorithm to segment cytoplasm and nucleus region from the background. Morphological operations are used for correcting the segmented output. Support vector machine classifier is used for classifying the smear cell as normal or abnormal based on the extracted features of the segmented output. The obtained accuracy of the classifier, sensitivity and specificity for single smear cell are 99.66%, 99.85% and 99.17%.