Automatic organ completion with image stitching for personalized radiation dosimetry in CT examinations.

Abstract

Computed tomography (CT) image-based patient-specific voxel-based dosimetry has difficulties complementing missing tissues for organs located partially inside or completely outside the image volume. Previous studies constructed patient-specific whole-body models by rescaling reference phantoms or extending regional CT images with manually adjusted phantoms. This study proposes a methodology for automatic organ completion of regional CT images for CT dosimetry using a stitching approach. Virtual clinical trials were performed by truncating whole-body CT images to generate virtual clinical chest and abdominopelvic CT images. Corresponding anchor images for each patient were selected according to sex and similarity of the axial length and water equivalent diameter of the virtual regional CT images. Automatic image stitching was performed by transformation initialization and iteration, while the stitched CT images and organ atlas were used in GPU-based Geant4 Monte Carlo simulations to generate a radiation dose map and absorbed organ dose. To evaluate the performance of the stitching model in radiation dosimetry, organ mass differences and Jaccard's coefficient of stitched and rescaled anchor images were calculated, and the radiation doses were compared among the corresponding values from the VirtualDose®, original whole-body CT, stitching model, regional CT, registration-based rescaling method, and WED-based rescaling method. The anatomical accuracy of stitched images was significantly improved. For organs partially inside the image volume, organ dose estimation from the stitching model could be more accurate than that reported in previous studies. The absolute differences in effective dose from the stitched images were 6.55% and 4.81% for chest and abdominopelvic CT scans, respectively. The proposed automatic stitching model partially complements organs inside or outside the CT scan range and provides more accurate anatomical representations for radiation dosimetry than traditional phantom rescaling methods.