Abstract
Cell-mediated immunity is a subject of intense interest in parasitology. Experiments with animals and observations on humans suggest that cell-mediated immunity is involved in protozoal infections (1). The inhibition of leukocyte migration has proved a suitable method for the <i>in vitro</i> study of cellular immunology. Søborg and Bendixen (2, 3) have successfully used this test with human peripheral leukocytes; Rosenberg and David (4) have shown it applicable to soluble antigens. In the present work we have attempted to obtain an <i>in vitro</i> test of the immune mechanisms in American trypanosomiasis. We observed the <i>in vitro</i> migration of peripheral leukocytes from patients with positive serology for <i>Trypanosoma cruzi</i> infection against soluble antigen. Materials and Methods. Blood. Two samples from each of 30 human adults were drawn: one, with heparin (Abbott 5000 U/ml with benzyl alcohol preservative) for the migration test, the other for the serologic tests.
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