Abstract
Abstract Delayed hypersensitivity was studied in chronic protozoal infection produced by the Trypanosoma cruzi (Chagas disease). Blood peripheral leukocyte migration inhibition was selected for studying cellular immune response in vitro. Two kinds of antigen preparations were used: a soluble extract of epimastigotes (SAg), and a modification of the antigen after its treatment with glutaraldehyde (MAg). When SAg was added to the medium no significant inhibition of migration was obtained in spite of using a concentration of antigen as high as 200 µg/ml. Similar results were obtained with normal cells. When the MAg was used, specific inhibition was obtained with chronic Chagas leukocytes. The inhibition was significant with a concentration of MAg as low as 5 µg/ml (p < 0.001).
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