Abstract
HUMAN lymphoblastoid cell lines (LCLs) have been derived from patients with acute and chronic leukaemias as well as from normal individuals1–3. Most of these LCLs express characteristics of bone marrow-derived (B) lymphocytes4,5 and contain the Epstein–Barr virus (EBV) genome6 and the EBV-determined nuclear antigen (EBNA)7. Cell lines derived from the blood of patients with myelogenous leukaemia also contain B lymphocyte markers4,8, which may indicate that they are not of leukaemic origin. In patients with lymphatic leukaemia, it has been less clear whether a derived LCL represents the neoplastic cell population. Recently, LCLs derived from patients with acute lymphoblastic leukaemia were found to possess characteristics of thymus-derived (T) lymphocytes3,5,9.
Published Version
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