Abstract
Among stem cells, autologous mesenchymal stem cells (MSCs) are ideal for transplantation by virtue of limited rejection reactions and marked proliferative ability. This study presents a novel method by which MSCs were harvested from the bone marrow of a patient who presented with severe post-traumatic infection and a non-healing skin defect in the hand, secondary to uncontrolled diabetes mellitus (DM). An autologous MSC suspension was injected into the persistent skin defect after stabilizing the blood glucose level and appropriate infection control. During the course of a regular 18-month postoperative follow-up, the patient exhibited immediate recovery with no transplant-associated complications, as well as no evidence of tumorigenicity. Thus, transplantation of autologous MSCs may play a role in the clinical application of stem cells, particularly for treatment of skin defects following surgery in cases of DM and for those caused by various other traumas.
Highlights
There are two types of stem cell in the human bone marrow: Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs)
It has been demonstrated in animal experiments that autologous bone marrow mononuclear cells implanted in ischemic limbs can differentiate into vascular endothelial cells to promote local angiogenesis, suggesting that stem cell transplantation can be used for the treatment of ischemic limb diseases and severe skin defects in cases of diabetes mellitus (DM) [5,6,7]
It has been demonstrated that skin constructed by MSCs used as seed cells can significantly promote healing of skin defects
Summary
LIU et al: AUTOLOGOUS BONE MARROW MSC TRANSPLANTATION FOR THE TREATMENT OF A SKIN DEFECT. Written, informed consent was obtained from the patient prior to autologous bone marrow MSC transplantation on the skin defect of the right hand in August, 2010. Following autologous bone marrow MSC transplantation, the injection puncture wounds healed rapidly. The local condition of the hand that underwent autologous bone marrow MSC transplantation was stable and no transplantation‐associated rejection reactions had occurred. H&E staining revealed mild epidermal hyperplasia with hyperkeratosis, increased pigment in local basal cells, hyperplasia and degeneration of collagen fibers, and minor infiltration of lymphocytes in the small perivascular regions of the superficial dermis These observations are not significantly different from the pathology of normal skin tissues.
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