Autologous Adipose Derived Stem Cell versus Platelet Rich Plasma Injection in the Treatment of Androgentic Alopecia: Efficacy, Side Effects and Safety

Abstract

Background: Platelet Rich Plasma (PRP) is based on the release of growth factors stimulating the initiation/ extension of anagen phase as well as promoting vascularization, Adipose Derived Stem Cell (AT-ADSCs) treatment were recently introduced as an alternative potential therapeutic application for hair growth. Objective: The aim of this study was to assess the efficacy side effects and safety of AT-ASCs and PRP in the treatment of androgentic alopecia. Patients and methods: Sixty randomized patients were treated by PRP, and AT-ASCs. Each patient was evaluated, and each lesion was treated by those modalities, patients received three sessions with one month interval for 3 months, follow up after 3 months. Results: A highly significant improvement <0.001 in terminal hair count of AT-ASCs group evaluated by video-dermoscopy assessment of AGA. That were confirmed by highly significant improvement in inter-mediate hair count and mean caliber (<0.001) associated with high incidence of side effects especially headache and erythema. In contrast, PRP group showed significant improvement 0.037 in terminal hair count and non-significant improvement in inter-mediate hair count and of mean caliber with minimum side effects. AT-ASCs showed a significant improvement in terminal hair count than PRP, Highly significant improvement in Inter-mediate hair count and hair caliber. Also, side effects of AT-ASCs showed highly significant pain, headache and erythema but no serious adverse events. Conclusion: Our study suggests that the There was significant improvement in AGA after PRP and highly significant after AT-ASCs therapy with significant difference of ADSC in terminal hair count and highly significant in caliber. Both modalities could effectively and safely be used to treat AGA.