Abstract
Autoimmune rheumatic diseases.
Highlights
Besides cardiovascular complications, renal disease and the risk of infection overshadow the outcome of patients with systemic lupus erythematosus (SLE) [5, 6]
The term autoimmune rheumatic diseases (ARDs) encompasses a heterogeneous group of conditions characterized by joint involvement along with a wide spectrum of systemic manifestations
Kow performed a comprehensive review of the mechanisms that are involved in endothelial damage. These authors focused on the factors involved in endothelial damage and repair and, in the development of cardiovascular disease (CVD) in patients with SLE. They discussed the relevant role of factors such as type 1 interferon, proinflammatory cytokines, inflammatory cells, immune complexes, costimulatory molecules, neutrophils extracellular traps, lupus-related autoantibodies, oxidative stress, and dyslipidemia that along with the aberrant function of the endothelial progenitor cells lead to endothelial dysfunction and increased susceptibility to develop CVD in patients with SLE
Summary
Renal disease and the risk of infection overshadow the outcome of patients with SLE [5, 6]. Amaya-Amaya and colleagues discussed the mechanisms associated with the increased risk of cardiovascular disease (CVD) in patients with autoimmune diseases. A good example of accelerated atherosclerosis in the setting of an ARD is SLE, in which endothelial dysfunction, an early step in the atherogenesis process, is observed before cardiovascular events can occur.
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