Abstract
Orthobiologics are helping surgeons to manipulate healing and reduce delayed unions and nonunions. Surgeons are no longer limited to harvesting the iliac crest to obtain osteoconductive, osteoinductive, and osteogenic materials for grafting purposes. Synthetic substitutes have evolved that have nearly unlimited volume, no associated harvest site morbidity, and may even eclipse the healing capabilities of autogenous grafts. Mesenchymal stem cells, available both by bone marrow aspirate harvest and by commercially available allografts, provide adjuncts to facilitate bone healing in foot and ankle surgery.
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