Abstract
We would like to thank Ms Michlovitz for her thoughtful and insightful comments. Ms Michlovitz accurately notes that there are some obvious limitations in using a model of delayed-onset muscle soreness (DOMS) to study the effects of salicylate phonophoresis. There is no question that research on the effects of physical agents must ultimately include studies on actual patient populations. We maintain, however, that DOMS is an attractive model for obtaining preliminary information on the effectiveness of salicylate phonophoresis. Ms Michlovitz makes the statement that “models for studies should be analogous to those actually representing clinical populations.” Although DOMS is not identical to other conditions, this model is indeed analogous to conditions that exhibit an inflammatory response leading to musculoskeletal pain and stiffness. The idea that acute inflammation appears to be the mechanism underlying DOMS was reinforced recently by Smith.1
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