Abstract
We thank Dr. Coleman for the interest in our article1 and for providing additional references regarding the historical use of l-dopa in dystonia. Because the frequently cited adage on the role of l-dopa in dystonia results from the impressive improvement of clinical symptoms seen in what were later coined dopa-responsive dystonias (DRDs), we specifically focused on these disorders in our “Historical Background” section (partly due to the restrictions in the number of words). Although we were not able to read the full text of all the articles cited by Dr. Coleman, they seem to be among the first to describe the response to l-dopa in dystonia in general and torsion dystonia in particular. Our literature review (“Therapeutic role in ‘non-DRDs’”), which aimed to describe the therapeutic role of l-dopa in a variety of disorders featuring dystonia and which covered the literature from 1995 to 2016, indicates that the benefits of this drug in torsion dystonia, most commonly due to DYT1 , are rather disappointing.
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