Author response: Building bridges between cellular and molecular structural biology

Ardan Patwardhan,Ilinca Tudose,Kay Grünewald,Irene Solanes Valero,Sriram Subramaniam,Sirarat Sarntivijai,Ingvar Lagerstedt,Martyn Winn,Helen Parkinson,Stephan Saalfeld,Matthew Mccormick ,Peter B Rosenthal ,Jason R Swedlow ,David N Mastronarde ,A Iudin ,Catherine L Lawson ,Martin L Jones ,David Gault ,Robert Brandt ,J.t Huiskonen ,Abraham J Koster ,Paul K Korir ,S.j Butcher ,Corey W Hecksel ,Lucy Collinson ,Helen R Saibil ,Gerard J Kleywegt

doi:10.7554/elife.25835.008

Author response: Building bridges between cellular and molecular structural biology

Ardan Patwardhan, Ilinca Tudose + Show 25 more

Open Access

https://doi.org/10.7554/elife.25835.008

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Publication Date: Jun 12, 2017
Citations: 9	License type: CC0 1.0

Affiliation: European Bioinformatics Institute, Wellcome Centre for Human Genetics, University of Oxford, National Cancer Institute, Center for Cancer Research, Science and Technology Facilities Council, Research Complex at Harwell, Janelia Research Campus, Howard Hughes Medical Institute, Kitware (United States), The Francis Crick Institute, University of Dundee, University of Colorado Boulder, Rutgers, The State University of New Jersey, Leiden University Medical Center, University of Helsinki, Baylor College of Medicine, Birkbeck, University of London, Institute of Structural and Molecular Biology

#Protein Data Bank In Europe #Structured Annotation + Show 8 more

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Abstract

The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.DOI: http://dx.doi.org/10.7554/eLife.25835.001

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