Augmented in vitro liver models with bioprinted liver organoids

Abstract

Bioprinted liver organoids (LOs) have emerged as a crucial tool for investigating patient-specific models and enhancing disease comprehension as well as overall patient care. These systems are comprised of liver-specific cell types along with suitable biomaterials to facilitate the printing process and provide a microenvironment for cell accommodation. Various printing technologies, such as jetting, extrusion, and stereolithography, each present distinct advantages and disadvantages concerning printing resolution, rheological properties, and biomaterial selection. Leveraging patient-derived cells, these models facilitate the development of personalized in vitro liver models, enabling the exploration of disease progression and drug efficacy. Advancing research on liver tissue-specific printable biomaterials and exploring designs that can effectively mimic the diverse functions of liver tissue will greatly expedite clinically relevant model development and augment patient care.