Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor

Ying Wu,Mark Von Itzstein,Santosh Rudrawar,George F Gao,Yan Wu,Qing Li,Jianxun Qi,Christopher J Vavricka,Robin J Thomson

doi:10.1007/s13238-015-0197-6

Ying Wu, Mark Von Itzstein + Show 7 more

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https://doi.org/10.1007/s13238-015-0197-6

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Abstract

Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor

Highlights

Influenza virus is a member of the Orthomyxoviridae family and is the causative agent of seasonal and pandemic flu
We reported that the 2009 pandemic H1N1 influenza virus NA (09N1) does not have a
We proposed that the I149V mutant may play a role in the unique 150-loop properties of 09N1

Summary

Introduction

Influenza virus is a member of the Orthomyxoviridae family and is the causative agent of seasonal and pandemic flu. In 2006, the first group 1 NA crystal structures of N1, N4 and N8 were solved and they all contained an additional cavity adjacent to the active site, the 150-cavity, which is formed by an open conformation of the 150-loop (residues 147–151) (Russell et al, 2006). It has been reported that group 1 specific inhibitor 3-(p-tolyl)allyl-Neu5Ac2en does work against 09N1 (Rudrawar et al, 2010).

Results

Conclusion