Abstract

In 2020 we published a case-series detailing patients who died from pancreatic cancer [1] (Appendix). These three patients were diagnosed with new-onset type 2 mellitus or deterioration of pre-existing type 2 diabetes shortly before their pancreatic malignancy was detected.

Highlights

  • In 2020 we published a case-series detailing patients who died from pancreatic cancer [1] (Appendix)

  • In the presented cases the diagnosis diabetes mellitus led not to the diagnosis of the underlying pancreatic carcinoma in such a timely manner that it contributed to survival

  • We will discuss the epidemiology of diabetes mellitus and pancreatic carcinoma, as well as factors contributing the diagnostic delay of and the poor survival associated with pancreatic carcinoma

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Summary

Introduction

In 2020 we published a case-series detailing patients who died from pancreatic cancer [1] (Appendix). We will try and summarize the key elements in their disease course that could be relevant for clinicians treating diabetes mellitus, especially in primary care For this purpose, we will discuss the epidemiology of diabetes mellitus and pancreatic carcinoma, as well as factors contributing the diagnostic delay of and the poor survival associated with pancreatic carcinoma. Leaving the general practitioner (GP) with no additional tools other than personal history, physical examination, and alertness, to identify this malignancy, that is often diagnosed too late In this commentary, accompanying the case-series, we discuss the relationship between diabetes mellitus and pancreatic carcinoma. Will try and summarize the key elements in their disease course that could be relevant for (primary care) clinicians treating diabetes mellitus with regards to a possible co-existing pancreatic carcinoma. Screening programs for familial associated pancreatic cancers are available, but these are not applicable for patients without known genetic burden [12]

A Reciprocal Relationship between Diabetes Mellitus and Pancreatic Cancer
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