Abstract
The effects of a high Mn intake on blood pressure, vascular reactivity and central catecholamine levels were studied in DOCA salt-hypertensive rats. High Mn intake inhibited blood pressure elevation in DOCA salt rats but did not modify it in normotensive rats. The blood pressure-lowering effect of Mn was associated with inhibited cardiac hypertrophy and increased natriuresis. Pharmacological studies in blood vessels showed that high Mn intake normalized vasoconstriction and sensitivity to norepinephrine of isolated and perfused mesenteric vascular beds from DOCA salt rats. Furthermore, high Mn intake improved the endothelium- and NO-dependent relaxation in isolated aortae from DOCA salt-hypertensive rats but not in those from normotensive rats. Norepinephrine levels were higher in the hypothalamus of DOCA salt-hypertensive rats than in those of normotensive rats, and high Mn intake decreased norepinephrine levels in hypothalamus of DOCA salt rats. In conclusion, a high Mn intake attenuated the development of hypertension with beneficial vascular and central effects. Mechanisms related to the pathophysiological development of DOCA salt hypertension may be involved.
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