Abstract
Attenuation of diabetic hepatopathy in alloxan-induced diabetic mice by methanolic flower extract of Phlogacanthus thyrsiflorus Nees
Highlights
Diabetes, termed as diabetes mellitus, is a major epidemic of this century (Shaw et al, 2010)
The present investigation is aimed to determine the effect of methanolic flower extract (MFE) of phlogacanthus thyrsiflorus on hyperglycemia, hyperlipidemia and oxidative stress in alloxan-induced diabetic mice
After treatment with MFE, 250 mg/kg bw dose was found to be effective in significantly reducing fasting blood glucose (FBG) level
Summary
Diabetes, termed as diabetes mellitus, is a major epidemic of this century (Shaw et al, 2010). The incidence of diabetes is rapidly increasing with estimates that the number will almost be doubled by 2030 (Wild et al, 2004). Diabetes mellitus is associated with insulin resistance, hyperlipidemia, hypertension (Taylor et al, 1994). It is linked with increased free radicals leading to compromise defense system (Saxena et al, 1993). The management of diabetes mellitus is considered to be a global problem and successful treatment has yet to be discovered. In India, indigenous remedies have been always used in the treatment of diabetes mellitus since the sixth century (Kashikar and Tejaswita, 2011).
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