Abstract
BackgroundAttention dysfunction has been observed among many kinds of nervous system diseases, including glioma. This study aimed to investigate the correlation between glioma localization, malignancy, postoperative recovery time and attention deficit.MethodsA total of 45 patients with glioma who underwent surgical resection and 18 healthy volunteers were enrolled. The attention network test, digital span test, color trail test II and Stroop test were used to detect the characteristics of attention deficit.ResultsOrientation network dysfunction was detected in the parietal lobe tumor group, and execution network deficit was detected in both the frontal and parietal lobe groups, while no significant difference was detected in the temporal lobe group compared to healthy controls. The high-grade glioma group (grade III-IV) exhibited more serious functional impairment than the low-grade group (grade I-II). No significant correlation was observed between postoperative recovery time and attention impairment.ConclusionsHigh-grade glioma patients suffer more severe attention impairment. In addition, the frontal and parietal lobe glioma patients suffer attention dysfunction in dissimilar manner. These findings will provide important guidance on the care of glioma patients after therapy.
Highlights
Attention dysfunction has been observed among many kinds of nervous system diseases, including glioma
We investigated the attention characteristics of 45 postoperative patients with glioma who discharged from our hospital between 2010 to 2012, as well as 18 healthy controls, and analyzed the relationship between tumor localization, malignancy, postoperative recovery time and attention dysfunction
Characteristics of the subjects Among the 45 glioma cases enrolled in this study, 15 gliomas were located in the frontal lobe, 12 in the parietal lobe and 18 in the temporal lobe; 13 cases were pathologically diagnosed as high-grade glioma and 32 cases as low-grade glioma according to the World Health Organization diagnostic criteria
Summary
Attention dysfunction has been observed among many kinds of nervous system diseases, including glioma. This study aimed to investigate the correlation between glioma localization, malignancy, postoperative recovery time and attention deficit. Glioma is the most common malignant intracranial tumor in adults, with a poor prognosis [1]. Posner and Petersen claimed that attention consists of three different networks (alerting, orienting and executing), based on neuronal function and neuronal anatomy, and concluded that the impairment of attention components is different in different injured brain regions [3]. The reduction in attention functionality has emerged as one of the most common postoperative complications of patients with glioma. We investigated the attention characteristics of 45 postoperative patients with glioma who discharged from our hospital between 2010 to 2012, as well as 18 healthy controls, and analyzed the relationship between tumor localization, malignancy, postoperative recovery time and attention dysfunction
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