Attempted Opacification of the Pancreas with the Use of Iodinated Dyes

Abstract

The recent report by Robert Shapiro (3), of experimental opacification of the pancreas in the rabbit by intravenous injection of a contrast material, has prompted an account of some previous experiments of a similar nature. Approximately three years ago a study was initiated in which attempts were made to opacify the pancreas in the dog following intravenous injection of iodinated dyes. Our initial studies were undertaken following the report of Ingraham and Visscher (1) on the excretion of aniline and other dyes from the pancreatic duct of dogs. They found that within two or three hours of injection the external secretion of the pancreas might contain as much as 5 per cent of the blood concentration of some of these dyes. Wool blue G, fast fuchsin B, rhodamine B, acridine red, indigo carmine, eosin BS, basic fuchsin, fluorescein, and methyl red were excreted from the pancreatic duct in amounts varying from 0.5 to 5 per cent of the blood concentration within a very short period. For our first attempts to ...