Abstract
Abstract : An attempt was made to clone rhesus marrow cells within the spleens of lethally irradiated rhesus monkeys. Twelve animals received autologous transplants; 2 animals received allogeneic transplants; and 4 animals served as irradiation controls. Ten days following transplantation (or irradiation, in the case of the controls) the animals were sacrificed and their spleens removed. No macroscopic nodules were found in any of the spleens; microscopic examination of subserial sections revealed scattered erythrocytic clones in 3 of 14 animals that received transplants. Reticulocyte counts, peripheral leukocytes, and cellularity of marrow spaces indicated that the transplanted marrow had proliferated in 13 of the 14 animals with transplants. Under our conditions, significant marrow cloning did not occur in spleens of lethally irradiated rhesus monkeys in a manner analogous to that described in similar studies with rodents.
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