Abstract
Atrial Fibrillation Susceptibility Alleles on Chromosome 4q25 Modulate Response to Catheter Ablation
Highlights
In the last five years, increasing evidence has emerged for a genetic predisposition to atrial fibrillation (AF)
Genome-wide association studies have been made possible by advances in genotyping technology that allow investigators to assay hundreds of thousands of single nucleotide polymorphisms (SNPs) spread over the entire human genome
In the first genome- wide association studies (GWAS) of AF, a strong association was discovered between AF and a haplotype block on chromosome 4q25.7 Within this locus, two non-coding SNPs were independently associated with AF and these findings were replicated in two populations of European descent and one of Asian descent
Summary
In the last five years, increasing evidence has emerged for a genetic predisposition to atrial fibrillation (AF). In a recent study published in the Journal of the American College of Cardiology, Husser et al.[13] examined whether the AF-susceptibility alleles on chromosome 4q25 were associated with AF recurrence after catheter ablation. The presence of either of the common polymorphisms (rs2200733 and rs10033464) on chromosome 4q25 was associated with in creased risk of both early and late AF recurrence.
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