Abstract
TTFields are low amplitude alternating electric fields which may interact with the membrane, spindle cell apparatus and other organelles of tumor cells. Preliminary data from a randomized phase III trial in patients with newly diagnosed glioblastoma suggest that the addition of TTFields to temozolomide-based chemoradiotherapy may prolong progression-free and overall survival. Here, we explored the effects of TTFields on glioma cells in vitro taking advantage of the inovitro™ system which allows the application of TTFields to cell cultures. Exposure to TTFields induced cell death in an intensity- and frequency-dependent manner in various human and mouse glioma cell lines. Similar effects were observed when TTFields were applied to glioma-initiating cell cultures. The combination of TTFields with irradiation or temozolomide reduced viability and clonogenic survival of LN-18 and LN-229 glioma cells in an additive manner. Further studies suggest that the application of TTFields reduces glioma cell migration as well as invasiveness. This dataset demonstrates that the application of electric fields may interfere with various biological key properties of glioma cells.
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