Abstract
1. 1. The activation of nonanedioic, decanedioic, dodecanedioic, tetradecanedioic, and hexadecanedioic acid was demonstrated in rat liver mitochondria. By our technique the activation of dicarboxylic acids shorter than nonanedioic acid could not be demonstrated. 2. 2. The activation capacity for hexadecanedioic acid in rat liver total homogenate was found to be 1.o μmole/min per g wet wt of tissue, i.e. about 10% of that for palmitic acid. 3. 3. Hexadecanedioic acid is activated by the mitochondrial and microsomal fractions. The subcellular distribution of this enzyme activity is almost identical to the distribution of palmitic acid activation. 4. 4. Hexadecanedioic and palmitic acid seemed to compete for the same enzyme. 5. 5. It is suggested that palmitic and hexadecanedioic acid are activated by the same enzyme(s).
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