Abstract
Adenosine 5′-triphosphate (ATP) evoked an inward current in whole-cell voltage-clamped adrenal chromaffin cells of the guinea pig. The reversal potential ( E rev) of ATP-evoked current was about 0 mV in normal external solution and was shifted towards negative potentials by substituting Tris + or sucrose, but not Ca 2+, for the extracellular Na +. This current was mediated by the activation of non-selective cation channels and had some different properties from nicotinic current. It is suggested that these channels may function as a part of the ATP-induced Ca 2+ influx pathway in guinea pig chromaffin cells.
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