TRPCs, GPCRs and the Bayliss effect

Abstract

An increase in pressure inside most small arteries unexpectedly results in a vasoconstriction. This phenomenon, known as the Bayliss effect, involves the stretch‐induced activation of non‐selective cation channels in the vascular smooth muscle cells. Recent work by Mederos y Schnitzler et al . now demonstrates that the stretch‐induced channel activity originates from a fascinating interplay between a TRP cation channel and the angiotensin receptor.