Abstract
Type 2 inflammation plays a central role in the pathogenesis of atopic dermatitis (AD) encompassing a specific CD4+ T helper type (Th) 2 cell response and the activation of other T-cell lineages, such as Th1, Th17/IL-23, and Th22 (Bakker et al., 2021). House dust mites (HDMs) allergens are likely the most relevant airborne allergen for AD in sensitized and genetically predisposed individuals worldwide (Calderón et al., 2015; Thomas, 2010). Accurate knowledge of the HDM allergens in the patient's environment turns out mandatory in the diagnosis and prescription of effective allergen immunotherapy (Bumbacea et al., 2020; González-Pérez and Poza-Guedes, 2021; González-Pérez et al., 2021).
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