Abstract
Perfusion becomes a reasonable alternative to traditional batch or fed-batch processes, partly due to the increasing availability of suitable re-usable or single-use equipment. High cell densities and long duration of perfusion processes require reliable process control. Amongst others, monitoring of cell stress becomes important. Intact cell MALDI-TOF mass spectrometry (ICM-MS) biotyping is described here as a robust at-line monitoring method of cell stress in perfusion cell culture.
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