Abstract
A series of nonpeptidic AT 1 selective angiotensin II (AII) antagonists containing a phenoxyphenylacetic acid element as a biphenyl tetrazole replacement have been identified. This series yielded compound 20 which exhibited binding affinities of AT 1 = 16 nM; AT 2 = 22 μM and demonstrated modest in vivo duration in blockade of AII pressor response in conscious rats after either i.v. or p.o. administration.
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