Abstract
BackgroundAfrican Americans (AA) having two high‐risk APOL1 alleles, termed G1 and G2, are about 7 times more likely to develop non‐diabetic kidney diseases, and ApoL1 is differentially expressed in glomerular arterial compartments in those with overt kidney disease.ObjectiveTo compare angiogenic cytokines in the urine of young, asymptomatic AA with high‐risk for CKD (G1 homozygotes) to lower‐risk AA (non‐carriers and heterozygotes).MethodsThirty‐seven previously genotyped participants (5 G1 homozygotes, 20 WT homozygotes, and 12 heterozygotes) donated mid‐stream, first morning urine samples. Cytokine concentrations in unprocessed urine samples were analyzed with Milliplex Human Cytokine/Chemokine Panel bead assay. Urine cytokine concentrations were standardized to urinary creatinine, and the two risk groups were compared using the Mann‐Whitney U Test (SPSS Version 21).ResultsConcentrations of the following angiogenic cytokines were significantly lower in high‐risk G1 homozygotes: TGF‐α (P=0.004), PDGF‐AA (P=0.016), IL‐1‐alpha (P=0.032), VEGF (P=0.036).ConclusionsThis pilot data indicates that young, asymptomatic African Americans with high‐risk APOL1 genotypes may have impaired angiogenesis. These results are consistent with prior evidence indicating that vascular disease may underlie ApoL1‐associated kidney diseases. This study was funded by a CTSA pilot award.
Published Version
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