Asymmetric synthesis of optically pure α-methyl-β,γ-unsaturated ketones via triethylaluminum-mediated stereospecific pinacol rearrangement of alkenyl groups

Abstract

Optically pure α-methyl-β,γ-unsaturated ketones are synthesized by the Et 3Al-mediated pinacol-type rearrangement where alkenyl groups migrate stereospecifically with complete retention of the olefin-geometry.