Asymmetric synthesis of α,α-disubstituted α-amino acid derivatives using MABR promoted rearrangement

Abstract

Abstract An efficient route for the asymmetric synthesis of α,α-disubstituted α-amino acids derivatives ( 1, 2 , and 3 ) starting from readily available epoxy silyl ethers ( 6 ) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chiral epoxide and Curtius rearrangement.