Abstract

AbstractStarting from propargyl alcohol (12), and on the basis of Zhou's modified Sharpless asymmetric epoxidation, the sex pheromone of the Gypsy moth, disparlure (+)‐8 and its enantiomer (−)‐8 have been synthesized, each in six steps, with overall yields of 29% for (+)‐8 and 27% for (−)‐8 (ee>98%). The use of the sequential coupling tactic renders the method flexible, which is applicable to the synthesis of other cis‐epoxy pheromones.

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