Abstract
Chirality is an important characteristic of several naturally occurring biological compounds. Thus, asymmetric synthesis i.e., generation of chiral centre in any synthetic compound during a reaction has drawn much attention of organic chemists. Various catalysts are being used by chemists for asymmetric synthesis but organocatalysts have been proved to be most powerful tool due to simple handling, inertness, and easy availability, non-toxicity, being metal-free and economic. Organocatalysis has become highly useful technique for asymmetric synthesis. Using this method various chiral heterocyclic compounds can be produced with high yield and optical purity. Here the synthesis of various chiral compounds is discussed using green methods, aldol reaction, Michael addition and various other methods. Synthesis of various chiral scaffolds found in biological active compounds and compounds having agrochemical, medicinal, pharmacological applications has also been discussed. Asymmetric synthesis using aqueous media is also discussed. The organocatalysts have been used successfully for a wide range of reactions making a large number of building blocks and other useful chiral compounds. Some of these reactions are: aldol reaction, Michael addition, cycloaddition reactions, synthesis of polymers etc. Asymmetric synthesis using organocatalysts leads to the formation of stereoisomers with diverse biological activities. Organocatalysis has emerged as a versatile and powerful technique for asymmetric synthesis. Being metal free, non-toxic and easy to handle, it does not harm environment and thus fits within the realm of green chemistry.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call