Abstract
In this paper the authors report the first catalytic enantioselective addition of arylboronic acids and alkenyl N-methyliminodiacetic acid (MIDA) boronate to β-substituted alkenylheteroarenes. Various types of substrates were employed, containing π-deficient quinoline, quinoxaline, pyrimidine moieties as well as π-excessive oxazole and oxadiazole fragments; the products were obtained in 56-91% yields and with 89-98% ee. Introduction of the alkenyl moiety could be accomplished via alkenyl MIDA boronates. Microwave irradiation could be replaced by thermal heating.
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