Abstract
BackgroundAstrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in diverse human cancers. The present study was aimed to investigate the clinical and prognostic significance of AEG-1 in salivary gland carcinomas (SGC).MethodsReal-time PCR and western blot analyses were employed to examine AEG-1 expression in two normal salivary gland tissues, eight SGC tissues of various clinical stages, and five pairs of primary SGC and adjacent salivary gland tissues from the same patient. Immunohistochemistry (IHC) was performed to examine AEG-1 protein expression in paraffin-embedded tissues from 141 SGC patients. Statistical analyses was applies to evaluate the diagnostic value and associations of AEG-1 expression with clinical parameters.ResultsAEG-1 expression was evidently up-regulated in SGC tissues compared with that in the normal salivary gland tissues and in matched adjacent salivary gland tissues. AEG-1 protein level was positively correlated with clinical stage (P < 0.001), T classification (P = 0.008), N classification (P = 0.008) and M classifications (P = 0.006). Patients with higher AEG-1 expression had shorter overall survival time, whereas those with lower tumor AEG-1 expression had longer survival time.ConclusionsOur results suggest that AEG-1 expression is associated with SGC progression and may represent a novel and valuable predictor for prognostic evaluation of SGC patients.
Highlights
Astrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in diverse human cancers
AEG-1 is up-regulated in salivary gland carcinomas (SGC) Western blot analysis revealed that AEG-1 protein was barely detectable in the two normal salivary gland tissues, whereas it was strongly expressed in all eight SGC biopsy tissues (Figure 1A)
We found that up-regulation of AEG-1 correlated with poor prognosis and reduced survival of patients with SGC
Summary
Astrocyte elevated gene-1 (AEG-1) is associated with tumorigenesis and progression in diverse human cancers. Salivary gland carcinoma (SGC) is a relatively rare cancer that accounts for less than 5% of all head and neck cancers [1,2] It is among the most complex malignancies owing to diverse histological characteristics and biological behaviors. AEG-1 can regulate human malignant glioma invasion through up-regulation of matrix metalloproteinase-9 and activating the NF-B signaling pathway [10,19,22,23]. These findings suggest that AEG-1 plays a dominant positive role in development and progression of diverse cancers
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