AST/ALT levels, MDA, and liver histopathology ofEchinometra mathaei ethanol extract on paracetamol-induced hepatotoxicity in rats.

Abstract

Echinometra mathaei was known to have potential antioxidant activities because it contains ofpolyhydroxy-naphthoquinone (echinochrome and spinochromes). The antioxidant properties contributed to the hepatoprotective effect by binding to free radicals compound that causes oxidative stress and necrosis in thehepatocytes. The research aimed to determine the hepatorepair effects of the E.mathaei ethanol extract onhigh-dose paracetamol-induced hepatic damage in Wistar rats. This research used a true experimental method. Thirty white male rats were divided into sixth groups, i.e.,normal control group, group II-VI was induced paracetamol 2,000mg/kg BW for three days. After paracetamol-induced, group III-VI was treated with curcumin 800mg/kg BW, E.mathaei extract 400, 800, and 1,200mg/kg BW for seven days. The hepatorepair parameter was obtained from AST/ALT, MDA tissue levels, and the number of hepatocyte necrosis cells. The data results were analyzed using the ANOVA test, followed by the LSD test to determine the difference between each treatment. The results showed that E.mathaei significantly (p<0.05) decreased the AST levels, MDA levels and the number of hepatocyte necrosis cells at a dose of 800mg/kg BW per orally treatment. The E. mathaei ethanol extract repaired the hepatic damage induced by paracetamol.