Abstract
This study investigated the effect of ethanol leaf extract of Spilanthes filicaulis on liver indices and selected biochemicals on carbon tetrachloride induced hepatic damage in wistar rats. A total of thirty (30) rats comprising of five (5) rats per group (90-130 g), were used for the study. Groups 1-3, served as normal, negative (CCl4 induced 1 mL/kg, 1:1 i.p.) and positive (CCl4 induced and administered with silymarin 50 mg/kg) controls respectively. Groups 4-6 were the extract treated groups administered with 250 mg/Kg bw, 500 mg/Kg bw and 750 mg/Kg bw respectively for 14 days. The results of the liver marker enzymes showed a significant decrease (p 0.05) in all treated groups when compared to the negative control group. Catalase (CAT) and Superoxide Dismutase (SOD) levels were significantly increased (p 0.05) in all treated groups when compared to the negative control. The study showed that the ethanol leaf extract of Spilanthes filicaulis has potential of restoring hepatic liver damage.
Highlights
Cellular metabolism is a vital process in the lives of living organisms, which account for the general activities of the cells which includes ATP production, protein translation, DNA transcription and RNA replication, redox signaling, xenobiotic detoxification etc
There was no significant difference in creatinine, urea and uric acid levels in all extract treated groups when compared to the negative control group
Calcium, chloride, phosphorus and bicarbonate levels showed no significant difference in all extract treated groups when compared to the negative control group
Summary
Cellular metabolism is a vital process in the lives of living organisms, which account for the general activities of the cells which includes ATP production, protein translation, DNA transcription and RNA replication, redox signaling, xenobiotic detoxification etc. These various processes are accompanied by some side reactions in some metabolic pathways which constantly generate Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) [1]. ROS and RNS production could mediate oxidative stress, a cellular state resulting from the equilibrium alteration between ROS production and the body defense system in favour of ROS generation [2] Exogenous radicals such as CCl3, a product from the biotransformation of CCl4, mediate hepatic and nephrone damage in experimental models [3]. The liver is susceptible to toxic effects associated with these air pollutants and there is urgent need to investigate medicinal plants that may confer protective effects in order to compliment the metabolic functions of the liver
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