Abstract
MicroRNAs (miRNAs) are an abundant class of endogenous small non-coding RNAs of 20-25 nucleotides in length that function as negative gene regulators. MiRNAs play roles in most biological processes, as well as diverse human diseases including cancer. Recently, many studies investigated the association between SNPs in miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs229283, miR-499 rs3746444 and colorectal cancer (CRC), which results have been inconclusive. PubMed, EMBASE, CNKI databases were searched with the last search updated on November 5, 2013. For miR-196a2 rs11614913, a significantly decreased risk of CRC development was observed under three genetic models (dominant model: OR = 0.848, 95%CI: 0.735-0.979, P = 0.025; recessive model: OR = 0.838, 95%CI: 0.721-0.974, P = 0.021; homozygous model: OR = 0.754, 95%CI: 0.627-0.907, P = 0.003). In the subgroup analyses, miR-196a2*T variant was associated with a significantly decreased susceptibility of CRC (allele model: OR = 0.839, 95%CI: 0.749-0.940, P = 0.000; dominant model: OR = 0.770, 95%CI: 0.653-0.980, P = 0.002; recessive model: OR = 0.802, 95%CI: 0.685-0.939, P = 0.006; homozygous model: OR = 0.695, 95%CI: 0.570-0.847, P = 0.000). As for miR-149 rs2292832, the two genetic models (recessive model: OR = 1.199, 95% CI 1.028-1.398, P = 0.021; heterozygous model: OR = 1.226, 95% CI 1.039-1.447, P = 0.013) demonstrated increased susceptibility to CRC. On subgroup analysis, significantly increased susceptibility of CRC was found in the genetic models (recessive model: OR = 1.180, 95% CI 1.008-1.382, P = 0.040; heterozygous model: OR = 1.202, 95% CI 1.013-1.425, P = 0.013) in the Asian group. These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC.
Highlights
Colorectal cancer (CRC) is the fourth most common cause of death from cancer and the most common malignancy of the gastrointestinal tract
For miR-196a2 rs11614913, a significantly decreased risk of CRC development was observed under three genetic models
Forty-five records were excluded for improper article titles and abstracts, including 25 records that did not explore CRC, 13 records that did not focus on Single nucleotide polymorphisms (SNPs) in miRNAs and 7 records that were not case-control study
Summary
Colorectal cancer (CRC) is the fourth most common cause of death from cancer and the most common malignancy of the gastrointestinal tract. SNP in miR-499) and the susceptibility of colorectal review; (4) no sufficient data were reported; (5) articles cancer (CRC) in different populations, but the results with obvious mistakes. We evaluated all potentially associated publications association between SNPs in miRNAs and susceptibility to retrieve the most eligible studies. The significance of the pooled ORs was determined by Eligible studies had to meet the following criteria: the Z-test, and P-value < 0.05 was considered statistically (1) evaluation of the associations between four SNPs in significant. When the existence of rs2292832 SNP in miR-149 and rs3746444 SNP in heterogeneity was detected (P-value < 0.10 for the Q-test, miR-499; (2) independent case-control design studies I2 >50%), the random-effects model (DerSimonian and for human; (3) sufficient genotype data were showed Laird method) was chosen (DerSimonian et al, 1986).
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