Abstract
Background: Women ageing with HIV undergo sex-specific changes. There is limited evidence available with regards to how the menopause impacts HIV outcomes. Objective: To investigate whether menopausal age is associated with engagement-in-care (EIC), viral load (VL) suppression and rebound among women living with HIV. Methods: Women were grouped by age (<40, 40–50, >50 years), corresponding to pre-, peri- and post-menopausal stages. EIC, HIV VL suppression (VL < 50 copies/mL) within 12 months of antiretroviral therapy initiation and VL rebound (two consecutive VL > 50 copies/mL) after VL suppression were compared across age groups using logistic/Cox proportional hazards regression. Associations were compared to those seen in heterosexual men. Results: Six thousand four hundred and fifty-five (6455) eligible women (median age 36 [interquartile range: 29–42], 64.4% black African, 19.1% white) contributed 44,226 person-years (PYRS) of follow-up; 29,846, 10,980 and 3,399 PYRS in those aged <40, 40–50 and >50, respectively. Women were engaged-in-care for 79.5% of follow-up time, 3,344 (78.0%) experienced VL suppression and 739 (22.1%) VL rebound. After adjustment, women aged >50 years had lower EIC than those aged <40. Women aged 40–50 were more likely to have VL suppression and were less likely to experience VL rebound than those aged <40 years. Trends in heterosexual men were similar for EIC but with no evidence of a higher VL suppression rate in those aged 40–50 years (p int. 0< .0001) and a stronger protective association between older age and VL rebound (p int. 0< .0001). Conclusion: Our findings warrant further research into the potential impact of the menopause to support women and clinicians through HIV care.
Highlights
In the UK, nearly a third of those living with HIV are women
We aim to investigate whether menopausal age is associated with engagement-in-care and virological outcomes among women participating in the UK Collaborative HIV Cohort (UK CHIC) study
A total of 6,455 heterosexual women in UK CHIC were included in analyses (Table 1); the women were enrolled at a median age of 36 [interquartile range, IQR: 29–42] years, and with a median CD4þ T-cell count of 287 [IQR: 140–463] cells/mm[3]
Summary
In the UK, nearly a third of those living with HIV are women. With successes in treatment, the increasing life expectancy of people living with HIV means this population is ageing; in 2018, 4.2% of women living with HIV were transitioning through the menopause and 33% were post-menopausal,[1] with theseWomen undergo sex-specific changes as they age, with hormone regulation. There is limited evidence available with regards to how these changes, the menopause, impact HIV outcomes. Women ageing with HIV undergo sex-specific changes. There is limited evidence available with regards to how the menopause impacts HIV outcomes. Objective: To investigate whether menopausal age is associated with engagement-in-care (EIC), viral load (VL) suppression and rebound among women living with HIV. Women were engaged-in-care for 79.5% of follow-up time, 3,344 (78.0%) experienced VL suppression and 739 (22.1%) VL rebound. Women aged 40–50 were more likely to have VL suppression and were less likely to experience VL rebound than those aged
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