Abstract
BackgroundBoth environmental and genetic factors are attributable to the incidence of noise-induced hearing loss (NIHL). The purpose of this study was to examine the associations between genetic variations in the EYA4, GRHL2 and DFNA5 genes and the risk to noise-induced hearing loss (NIHL) in a Chinese population.MethodsA case–control study was conducted with 476 NIHL workers and 475 normal hearing workers matched with gender, years of noise exposure, and intensity of noise exposure. Twelve tag single-nucleotide polymorphisms (SNP) in the EYA4, GRHL2 and DFNA5 genes were genotyped using nanofluidic dynamic arrays on the Fluidigm platform. Multiple logistic regression was used to analyze the associations of genetic variations with NIHL adjusted by age, smoking/drinking status, and cumulative noise exposure and their interactions with noise exposure.ResultsThe SNPs of rs3777781and rs212769 in the EYA4 gene were significantly associated with NIHL risk. In rs3777781, comparing with the subjects carrying with TT types, the carriers with AT and AA genotypes had the decreased risk of NIHL (OR = 0.721, 95 % CI = 0.522 - 0.996). In rs212769, the AG and AA carriers had increased NIHL risk (OR = 1.430, 95 % CI = 1.014 - 2.016) compared with the subjects with GG genotype. Rs666026 in the associated GRHL2 gene and rs2521758 in the DFNA5 gene were marginally t associated with NIHL (P = 0.065 and 0.052, respectively). Rs2521758 and rs212769 had significantly interacted with noise exposure (P < 0.05).ConclusionsGenetic variations in the EYA4, GRHL2 and DFNA5 genes and their interactions with occupational noise exposure may play an important role in the incidence of NIHL.
Highlights
Noise is the most widespread environmental pollution that exposed in the occupational and living environment
No significant differences were found between noise-induced hearing loss (NIHL) and normal hearing groups in the distributions of smoking and drinking status, years of noise exposure, median of noise intensities (P > 0.05)
This study examined the associations of 12 single-nucleotide polymorphisms (SNP) in Eyes absent homolog 4 (EYA4), Grainyhead like 2 (GRHL2) and DFNA5 genes with the risk of NIHL
Summary
Noise is the most widespread environmental pollution that exposed in the occupational and living environment. We found that the genetic variants in the PCDH15 gene were associated with NIHL risk and this variant modified the biological effect induced by occupational-noise exposure [14]. Zhang et al Environmental Health (2015) 14:77 the known genetic polymorphisms only explained a small part of the etiology in NIHL. Both environmental and genetic factors are attributable to the incidence of noise-induced hearing loss (NIHL). The purpose of this study was to examine the associations between genetic variations in the EYA4, GRHL2 and DFNA5 genes and the risk to noise-induced hearing loss (NIHL) in a Chinese population
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