Abstract
BackgroundThe aim of this study was to screen for noise-induced hearing loss (NIHL)-associated single nucleotide polymorphisms (SNPs) and to construct genetic risk prediction models for NIHL in a Chinese population.MethodsFour hundred seventy-six subjects with NIHL and 476 matched controls were recruited from a cross-sectional survey on NIHL in China. A total of 83 candidate SNPs were genotyped using nanofluidic dynamic arrays on a Fluidigm platform. NIHL-associated SNPs were screened with a multiple logistic model, and a genetic risk model was constructed based on the genetic risk score (GRS). The results were validated using a prospective cohort population.ResultsSeven SNPs in the CDH23, PCDH15, EYA4, MYO1A, KCNMA1, and OTOG genes were significantly (P < 0.05) associated with the risk of NIHL, whereas seven other SNPs were marginally (P > 0.05 and P < 0.1) associated with the risk of NIHL. A positive correlation was observed between GRS values and odds ratio (OR) for NIHL. Two SNPs, namely, rs212769 and rs7910544, were validated in the cohort study. Subjects with higher GRS (≧9) showed a higher risk of NIHL incidence with an OR of 2.00 (95% CI = 1.04, 3.86).ConclusionsGenetic susceptibility plays an important role in the incidence of NIHL. GRS values, which are based on NIHL-associated SNPs. GRS may be utilized in the evaluation of genetic risk for NIHL and in the determination of NIHL susceptibility.
Highlights
Noise exposure is one of the most common occupational risk factors and have several detrimental effects on health, including irritability, insomnia, fatigue, and hearing loss [1]
A total of 476 Noise-induced hearing loss (NIHL) and 476 control subjects were recruited from the cross-sectional study for screening of NIHL-associated Single-nucleotide polymorphism (SNP)
Besides rs11004085 in the PCDH15 gene, rs3777781 and rs3777849 in eyes absent 4 homolog (EYA4), and rs2521768 in DFNA5 that we have reported before [18, 19], additional 10 SNPs were found to be associated with NIHL risk
Summary
Noise exposure is one of the most common occupational risk factors and have several detrimental effects on health, including irritability, insomnia, fatigue, and hearing loss [1]. Noise-induced hearing loss (NIHL) is a worldwide occupational health risk and the second most frequent form of sensorineural hearing loss, after age-related hearing impairment (ARHI) [2]. Under similar levels of noise exposure, workers may suffer different intensity of hearing damage. The differences indicate that genetic susceptibility plays an important role in the incidence of NIHL under noise-exposure environment. The aim of this study was to screen for noise-induced hearing loss (NIHL)-associated single nucleotide polymorphisms (SNPs) and to construct genetic risk prediction models for NIHL in a Chinese population
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Environmental health : a global access science source
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
