Abstract
ADIPOQ gene polymorphisms have been indicated to be associated with hypertension; however, published studies have reported inconsistent results. Eligible studies were retrieved by searching the PubMed, Embase and China National Knowledge Infrastructure databases. The case group consisted of patients with hypertension, and the control group consisted of subjects with normal blood pressure. Based on eleven published articles, involving 4837 cases and 5618 controls, the pooled results from rs2241766 polymorphism showed increased risk in the allelic model (G VS T: OR = 1.16, 95%CI = 1.06–1.27), recessive model (GG VS GT + TT: OR = 1.34, 95%CI = 1.10–1.63), dominant model (GG + GT VS TT: OR = 1.15, 95%CI = 1.02–1.30) and homozygote model (GG VS TT: OR = 1.38, 95%CI = 1.21–1.69). In addition, rs266729 polymorphism showed increased risk for hypertension in the recessive model (GG VS GC + CC: OR = 1.43, 95%CI = 1.02–2.01). In the Caucasian subgroup, rs1501299 polymorphism showed decreased risk of hypertension in the allelic model (T VS G: OR = 0.75, 95%CI = 0.58–0.97), dominant model (TT + TG VS GG: OR = 0.83, 95%CI = 0.71–0.98) and heterozygote model (TG VS GG: OR = 0.82, 95%CI = 0.68–0.99). The rs2241766 polymorphism was associated with a significant increase in hypertension risk based on our analysis. Moreover, an increased risk of rs266729 in hypertension patients was also detected. Our meta-analysis suggests that the rs1501299 polymorphism may play a protective role in hypertension in Caucasian subgroup; however, this finding requires further study.
Highlights
Hypertension is a major risk factor for vascular disease and the leading source of global health burden[1]
For rs2241766, 12 studies were included with 2147 cases and 2601 controls; 9 studies with 1859 cases and 2109 controls are included for rs1501299; only 5 studies with 831 cases and 908 controls concerning the rs266729 and hypertension risk are included
Endothelial dysfunction plays an important role in the pathogenesis of hypertension[30,31,32,33]
Summary
Hypertension is a major risk factor for vascular disease and the leading source of global health burden[1]. The aetiology of hypertension has not been fully elucidated, interactions between genes and environmental factors are suggested to play an important role in the pathological process of hypertension[2]. Several single-nucleotide polymorphisms (SNPs) in the ADIPOQ gene have been described[11]. Most of the published studies have investigated the associations of rs2241766, rs1501299 and rs266729 polymorphisms in the ADIPOQ gene with risk factors of hypertension[15,16,17,18]. The small numbers and varying populations of the published studies may partially account for the controversial results. We performed this meta-analysis to investigate the associations between ADIPOQ rs2241766, rs1501299 and rs266729 polymorphisms and hypertension
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