Abstract
ADIPOQ gene polymorphisms were indicated to be associated with coronary artery disease (CAD) in diabetic patients, however, published studies reported inconsistent results. We performed this meta-analysis to reach a more accurate estimation of the relationship between two common ADIPOQ genetic polymorphisms (rs2241766 and rs1501299) and CAD risk in diabetic patients. Eligible studies were retrieved by searching PubMed, Embase, Wangfang, VIP database and China National Knowledge Infrastructure databases. Included and excluded criteria were formulated. The case group was diabetic patients with CAD, and the control group was diabetic subjects without CAD. Summary odds rations (ORs) and 95% confidence intervals (CIs) were used to evaluate ADIPOQ polymorphisms associations with CAD risk in diabetic group. Heterogeneity was evaluated by Q statistic and I2 statistic. A total of twelve published articles, involving 3996 cases and 8876 controls were included in this meta-analysis. The pooled results from rs1501299 polymorphism showed decreased risk in homozygote model (TT VS GG: OR=0.67, 95%CI=0.54-0.83). Heterogeneity was detected in our study. Sensitivity analysis and subgroup analysis were conducted in the meta-analysis. For rs2241766 polymorphism, an increased risk was detected in Caucasian subgroup in heterozygote model (CT VS TT: OR=1.19, 95%CI=1.00-1.42). In genotyping method (PCR-RFLP) subgroup, an increased risk was found in recessive model (GG VS GT+TT: OR=2.05, 95%CI=1.23-3.39). In the sensitivity analysis of rs1501299, decreased risk was detected in allelic model (T VS G: OR=0.86, 95%CI=0.76-0.98) and recessive model (TT VS TG+GG: OR=0.47, 95%CI=0.33-0.67). Publication bias is not observed in our results. Our meta-analysis suggests that the rs1501299 polymorphism may play a protective role in CAD in diabetic patients. The rs2241766 polymorphism is found to be associated with a significant increase in CAD risk in Caucasian and genotyping method (PCR-RFLP) subgroups. Further studies are needed to confirm the prediagnostic effect of the two gene polymorphisms in CAD risk in diabetic patients.
Highlights
Type 2 diabetic mellitus (T2DM) is the predominant type of diabetic mellitus which is a complex metabolic disorder with hereditary and environmental factors.[1]
Our meta-analysis suggests that the rs1501299 polymorphism may play a protective role in coronary artery disease (CAD) in diabetic patients
[13] Since plasma adiponectin level is affected by genetic factors such as single-nucleotide polymorphisms in the adiponectin gene (ADIPOQ), many studies about the associations between the polymorphisms of ADIPOQ and CAD, T2DM, Obesity and insulin resistance have been reported
Summary
Type 2 diabetic mellitus (T2DM) is the predominant type of diabetic mellitus which is a complex metabolic disorder with hereditary and environmental factors.[1]. The gene coding for adiponectin, ADIPOQ, is located on chromosome 3q27, which is the susceptible locus for CAD and T2DM.[10, 11] A wide range of anti-athergenic effects of adiponectin is reported.[12] Its genetic deficit could increase the risk of CAD in both general population and patients with type 2 diabetes. [13] Since plasma adiponectin level is affected by genetic factors such as single-nucleotide polymorphisms in the adiponectin gene (ADIPOQ), many studies about the associations between the polymorphisms of ADIPOQ and CAD, T2DM, Obesity and insulin resistance have been reported. Our meta-analysis aims to pool current evidence together for better understanding of the potential associations between the rs2241766 and rs1501299 polymorphisms and CAD risk in type 2 diabetic patients
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