Abstract
A genome-wide association study (GWAS) in Chinese twins was performed to explore associations between genes and pulse pressure (PP) in 2012, and detected a suggestive association in the phosphatase and actin regulator 1 (PHACTR1) gene on chromosome 6p24.1 (rs1223397, P=1.04e−07). The purpose of the present study was to investigate associations of PHACTR1 gene polymorphisms with PP in a Chinese population. We recruited 347 subjects with PP ≥ 65 mmHg as cases and 359 subjects with 30 ≤ PP ≤ 45 mmHg as controls. Seven single nucleotide polymorphisms (SNPs) in the PHACTR1 gene were genotyped. Logistic regression was performed to explore associations between SNPs and PP in codominant, additive, dominant, recessive and overdominant models. The Pearson’s χ2 test was applied to assess the relationships of haplotypes and PP. The A allele of rs9349379 had a positive effect on high PP. Multivariate logistic regression analysis showed that rs9349379 was significantly related to high PP in codominant [AA vs GG, 2.255 (1.132–4.492)], additive [GG vs GA vs AA, 1.368 (1.049–1.783)] and recessive [AA vs GA + GG, 2.062 (1.051–4.045)] models. The positive association between rs499818 and high PP was significant in codominant [AA vs GG, 3.483 (1.044–11.613)] and recessive [AA vs GG + GA, 3.716 (1.119–12.339)] models. No significant association of haplotypes with PP was detected. There was no significant interaction between six SNPs without strong linkage. In conclusion, the present study presents that rs9349379 and rs499818 in the PHACTR1 gene were significantly associated with PP in Chinese population. Future research should be conducted to confirm them.
Highlights
Pulse pressure (PP) is the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP), reflecting the fluctuation of blood pressure during each cardiac contraction [1,2]
The case–control study was performed from July 2015 to December 2017, among subjects residing in four districts (Shibei, Shi’nan, Huangdao, Licang) of Qingdao, China
Previous studies have revealed that PP is closely associated with polymorphisms of many genes, such as endothelial nitric oxide synthase gene, angiotensin-converting enzyme (ACE) gene and fibrillin-1 gene [54,55,56,57]
Summary
Pulse pressure (PP) is the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP), reflecting the fluctuation of blood pressure during each cardiac contraction [1,2]. Widening PP is an independent risk factor for coronary heart disease (CHD), myocardial infarction (MI), stroke and is linked to mortality [3,4,5,6]. Studies have demonstrated that some environmental factors affect PP. Reduced arterial compliance in large arteries with age leads to elevated PP [7]. Gender affects PP through changing the time for return of the reflected wave, dependent on body height [8]. PP might be influenced by cholesterol, diabetes and hypertension [2]
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