Abstract
Background H19 polymorphisms have been reported to correlate with an increased susceptibility to a few types of cancers, although their role in neuroblastoma has not yet been clarified.Materials and methods We investigated the association between three single polymorphisms (rs2839698 G>A, rs3024270 C>G, and rs217727 G>A) and neuroblastoma susceptibility in Chinese Han populations. Three hundred ninety-three neuroblastoma patients and 812 healthy controls were enrolled from the Henan and Guangdong provinces. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to determine the strength of the association of interest.Results Separated and combined analyses revealed no associations of the rs2839698 G>A, rs3024270 C>G or rs217727 G>A polymorphisms and neuroblastoma susceptibility. In the stratification analysis, female children with rs3024270 GG genotypes had an increased neuroblastoma risk (adjusted OR = 1.61, 95% CI = 1.04–2.50, P=0.032).Conclusion The rs3024270 GG genotype might contribute to an increased neuroblastoma susceptibility in female Chinese children.
Highlights
H19 polymorphisms have been reported to correlate with an increased susceptibility to a few types of cancers, their role in neuroblastoma has not yet been clarified
Single nucleotide polymorphisms (SNPs) or other gene mutations, such as rare mutations in the anaplastic lymphoma kinase (ALK) gene at locus 2p23 for familial neuroblastoma, common single nucleotide polymorphism (SNP) in cancer susceptibility candidate 15 (CASC15) and neuroblastoma-associated transcript 1 (NBAT1) at 6p22 were found to be involved in tumor initiation of neuroblastoma, and the bos taurus BRCA1 associated RING domain 1 (BARD1) gene at 2q35, IL3, cholesterol-lowering factor (CFL), and lens intrinsic membrane (LIM) domain only 1 (LMO1) were found to be related to the risk of sporadic neuroblastoma
None of the three SNPs were found to be associated with an increased neuroblastoma risk in the separate analyses of each SNP or in the combined analysis on protective genotypes of the three SNPs
Summary
H19 polymorphisms have been reported to correlate with an increased susceptibility to a few types of cancers, their role in neuroblastoma has not yet been clarified. Evidence from genome-wide association studies (GWASs) of sporadic cases suggests that genetic factors might be involved in the pathogenesis of neuroblastoma [9,10]. These studies indicate an important role of genetic characteristics in the tumorigenesis of neuroblastoma. Single nucleotide polymorphisms (SNPs) or other gene mutations, such as rare mutations in the ALK gene at locus 2p23 for familial neuroblastoma, common SNPs in cancer susceptibility candidate 15 (CASC15) and neuroblastoma-associated transcript 1 (NBAT1) at 6p22 were found to be involved in tumor initiation of neuroblastoma, and the bos taurus BRCA1 associated RING domain 1 (BARD1) gene at 2q35, IL3, cholesterol-lowering factor (CFL), and lens intrinsic membrane (LIM) domain only 1 (LMO1) were found to be related to the risk of sporadic neuroblastoma
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