Abstract
Neuroblastoma is a lethal tumor that commonly occurs in children. Polymorphisms in XPD reportedly influence risk for several types of cancer, though their roles in neuroblastoma remain unclear. Here we endeavored to determine the relevance of XPD gene polymorphisms and neuroblastoma susceptibility in Chinese children genotyping three XPD polymorphisms (rs3810366, rs13181 and rs238406) in 505 cases and 1070 controls and assessing their contributions to neuroblastoma risk. Overall, we detected no significant association between any single XPD genotype and neuroblastoma risk. When risk genotypes were combined, however, we found that patients with 2-3 risk genotypes were more likely to develop neuroblastoma (adjusted odds ratio =1.31; 95% confidence interval =1.06-1.62, P=0.013) than those with 0-1 risk genotypes. Stratification analysis of rs3810366 revealed significant relationships between the subgroups age ≤18 months and clinical stage I+II+4s and neuroblastoma risk. Moreover, the presence of 2-3 risk genotypes was significantly associated with increased neuroblastoma risk in the subgroups age ≤18 months, male, tumor originated from others, and clinical stage I+II+4s. Our findings provide novel insight into the genetic underpinnings of neuroblastoma and demonstrate that XPD polymorphisms may have a cumulative effect on neuroblastoma risk.
Highlights
Neuroblastoma, a solid tumor of the sympathetic nervous system, remains the most commonly occurring lethal cancer among children [1], accounting for 7%10% of all cancers in children under 15 years of age [2, 3]
The genotype frequencies for the three selected XPD polymorphisms in all subjects and in selected subject groups and their contributions to neuroblastoma risk are summarized in Table 1 and Supplemental Table 2
Nova Program of Guangzhou (No) single XPD polymorphism was significantly associated with neuroblastoma risk in any genetic model evaluated
Summary
Neuroblastoma, a solid tumor of the sympathetic nervous system, remains the most commonly occurring lethal cancer among children [1], accounting for 7%10% of all cancers in children under 15 years of age [2, 3]. The prevalence of neuroblastoma in the United States is about 1 in 7000 [4], but is only about 1 in www.aging-us.com Genotype Cases (N=505). Adjusted OR (95% CI) b rs3810366 (HWE=0.143) GG GC 1.23 (0.95-1.60)
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