Abstract
Severe asthma is asthma that is uncontrolled despite adherence with optimized high-dose inhaled corticosteroid and long-acting β-agonist therapy and exclusion of other contributory factors, or that worsens when high-dose treatment is decreased.1 Patients with severe asthma are considered a separate group from those with mild or moderate asthma, due to the need for—and benefit from—systematic and multidisciplinary evaluation, accurate phenotyping, and associated high-cost treatments.2 Poor asthma control is associated with work absenteeism and loss of productivity,3 but data regarding the determinants of work ability in severe asthma are sparse; limited data from cross-sectional studies outside the United Kingdom have shown associations with disease severity, and poor physical and mental health status.
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