Abstract
Osteoarthritis (OA) causes oxidative stress. Coenzyme Q10 is an antioxidant that participates in energy production in the human body. The purpose of this study was to investigate the relationships among coenzyme Q10 status, oxidative stress, antioxidant capacity, and muscle function in patients with OA. This case-control study recruited 100 patients with OA and 100 without OA. The coenzyme Q10 status, oxidative stress, antioxidant capacity, muscle mass (by dual-energy X-ray absorptiometry), muscle strength (hand-grip and leg-back strength), and muscle endurance (dumbbell curls, gait speed, chair-stand test, and short physical performance battery) were measured. The results showed that both OA and elderly subjects had a low coenzyme Q10 status (<0.5 μM). Oxidative stress was significantly negatively correlated with muscle function (protein carbonyl, p < 0.05). Coenzyme Q10 level was positively associated with antioxidant capacity, muscle mass, muscle strength and muscle endurance in patients with OA (p < 0.05). Since OA is an age-related disease, coenzyme Q10 may be consumed by oxidative stress and thereby affect muscle function. Raising coenzyme Q10 in patients with OA could be suggested, which may benefit their antioxidant capacity and muscle function.
Highlights
Osteoarthritis (OA) is an age-related chronic disease that leads to joint pain, stiffness, and physical impairment [1]
Regarding the level of muscle mass, muscle strength, and muscle endurance stratified by age, patients with OA in the elderly (p = 0.07) and middle-aged groups (p = 0.01) had significantly lower gait speed than Non-OA
We further examined the correlations between coenzyme Q10 status and oxidative stress, muscle mass, muscle strength, and muscle endurance after stratification by age (Table 3)
Summary
Osteoarthritis (OA) is an age-related chronic disease that leads to joint pain, stiffness, and physical impairment [1]. In addition to risk factors (obesity or aging), the progression of OA is related to the accumulation of reactive oxygen species (ROS), which may regulate the secretion of cytokines and apoptosis to affect intracellular metabolism in chondrocytes [3]. The increased oxidative stress molecules may attack proteins and affect skeletal muscle function in elderly individuals [6,7], and it may increase the risk of sarcopenia in patients with OA [8]. Antioxidant status or antioxidant capacity can protect cells from oxidative stress damage caused by diseases. The association of antioxidant status and muscle function is not clear, especially for patients with OA who have a high risk of limited mobility. We investigated the relationships between oxidative stress, antioxidant capacity, muscle mass and muscle strength in patients with OA in this study
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