Coenzyme Q10 and Oxidative Stress: Inflammation Status in Hepatocellular Carcinoma Patients after Surgery.

Hsiao-Tien Liu,Yi-Chia Huang,Ping-Ting Lin,Yin-Tzu Huang,Shao-Bin Cheng

doi:10.3390/nu9010029

Abstract

(1) Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide, and surgical resection is the main treatment for HCC. To date, no published study has examined the status of coenzyme Q10 in patients with HCC after surgery. Thus, the purpose of this study was to investigate the correlations between the level of coenzyme Q10, oxidative stress, and inflammation in patients with HCC after surgery; (2) Methods: 71 primary HCC patients were recruited. Levels of coenzyme Q10, vitamin E, oxidative stress (malondialdehyde), antioxidant enzymes activity (superoxidase dismutase, catalase, and glutathione peroxidase), and inflammatory markers (high sensitivity C-reactive protein; tumor necrosis factor-α; and interleukin-6) were measured; (3) Results: Patients with HCC had a significantly lower levels of coenzyme Q10 (p = 0.01) and oxidative stress (p < 0.01), and significantly higher levels of antioxidant enzymes activities and inflammation after surgery (p < 0.05). The level of coenzyme Q10 was significantly positively correlated with antioxidant capacity (vitamin E and glutathione peroxidase activity) and negatively correlated with inflammation markers after surgery; (4) Conclusion: Hepatocarcinogenesis is associated with oxidative stress, and coenzyme Q10 may be considered an antioxidant therapy for patients with HCC, particularly those with higher inflammation after surgery.

Highlights

The most recent reports from the World Health Organization (WHO, 2014) and the Ministry of Health and Welfare (2014) in Taiwan indicated that hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths [1,2]
Patients with HCC suffer from study, we found that the level of coenzyme Q10 was significantly correlated with vitamin E and a higher level of oxidative stress and inflammation [27], and a deficiency in coenzyme Q10 was found antioxidant enzyme (GPx) activity in HCC patients (Figure 1)
Patients with HCC suffer from a higher in HCC patients, we suggest that the administration of coenzyme Q10 supplements in patients with level of oxidative stress and inflammation [27], and a deficiency in coenzyme Q10 was found in HCC

Summary

Introduction

The most recent reports from the World Health Organization (WHO, 2014) and the Ministry of Health and Welfare (2014) in Taiwan indicated that hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths [1,2]. Surgical resection is the main treatment for primary HCC [3]. During or after surgical procedures, there is a physiological stress response that involves activation of inflammatory, endocrine, metabolic, and immunological mediators [4]. Oxidative stress, which is defined as a disturbance in the balance between the productions of reactive oxygen species (ROS) and antioxidant defenses [5]. The increase in the oxidative stress during or after surgery may be associated with increasing complications such as myocardial injury, sepsis, pulmonary edema, kidney and liver failure, and increased mortality [4,6,7]. Oxidative stress and inflammation status is related to the prognosis of the disease after surgery in HCC patients

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